Somatoform Disorders Clinical Trial
— PERCMO-TNFOfficial title:
Study of Subjective Perception of Motor Control During Psychogenic Disorders : Brain Mechanisms and Functional Imaging.
NCT number | NCT02843932 |
Other study ID # | 38RC14.120* |
Secondary ID | |
Status | Terminated |
Phase | N/A |
First received | |
Last updated | |
Start date | May 13, 2015 |
Est. completion date | June 2019 |
Verified date | November 2020 |
Source | University Hospital, Grenoble |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The aim of this study is to reveal neurobiological bases of the motor control of conscious perception, thanks to new techniques of functional cerebral imaging (MRI), and potentials deteriorations connected to neuropsychiatric disorders like conversion disorder. The Hospital University Center of Grenoble will provide patients from Neurology department, characterized with non psychogenic epileptic seizures and abnormal psychogenic movements, from conversive origin. Subjects will be scanned by Magnetic Resonance Imaging during a motor paradigm inducing a perceptive conflict between two informations : proprioceptive information coming from the action (drawing) and visual information (draw's mark) that appears on the screen when there is movement.
Status | Terminated |
Enrollment | 14 |
Est. completion date | June 2019 |
Est. primary completion date | June 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility | Inclusion Criteria: - Signed informed consent - Medical exam médical done before study participation - Between 18 and 65 years - Right-handed persons - Conversion disorder based on DSM IV-R criterias - Symptom affecting motor system, like abnormal movements (shivers, dystonia, parkinsonism, or problem when walking) Exclusion Criteria: - Subjects included in a clinical and/or therapeutic exeprimentation in progress - People with MRI contraindications : prosthesis or metal implants, metallic teeth (dental) brace, pacemaker, IUD, possibility of pregnancy, claustrophobia - Traitement médicamenteux psychotrope ou susceptible d'interférer avec le débit sanguin cérébral ou l'activité neuronale - History of brain or disseminated and extendible lesions of white matter, of an other degenerative morbidity, a confusion or an insanity as well as serious deficits preventing language understanding. - Alcohol ingestion - Pregnant, parturient or breastfeeding women - All other categories of protected persons |
Country | Name | City | State |
---|---|---|---|
France | Chu Grenoble | Grenoble |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Grenoble |
France,
Blakemore SJ, Wolpert DM, Frith CD. Abnormalities in the awareness of action. Trends Cogn Sci. 2002 Jun 1;6(6):237-242. — View Citation
Carson AJ, Stone J, Warlow C, Sharpe M. Patients whom neurologists find difficult to help. J Neurol Neurosurg Psychiatry. 2004 Dec;75(12):1776-8. — View Citation
Cojan Y, Vuilleumier P. Functional brain imaging of psychogenic paralysis during conversion and hypnosis
Cojan Y, Waber L, Carruzzo A, Vuilleumier P. Motor inhibition in hysterical conversion paralysis. Neuroimage. 2009 Sep;47(3):1026-37. doi: 10.1016/j.neuroimage.2009.05.023. Epub 2009 May 18. — View Citation
de Lange FP, Roelofs K, Toni I. Increased self-monitoring during imagined movements in conversion paralysis. Neuropsychologia. 2007 May 15;45(9):2051-8. Epub 2007 Feb 11. — View Citation
de Lange FP, Roelofs K, Toni I. Motor imagery: a window into the mechanisms and alterations of the motor system. Cortex. 2008 May;44(5):494-506. doi: 10.1016/j.cortex.2007.09.002. Epub 2007 Dec 23. — View Citation
Desmurget M, Grafton S. Forward modeling allows feedback control for fast reaching movements. Trends Cogn Sci. 2000 Nov 1;4(11):423-431. — View Citation
Fourneret P, Jeannerod M. Limited conscious monitoring of motor performance in normal subjects. Neuropsychologia. 1998 Nov;36(11):1133-40. — View Citation
Friston KJ, Holmes AP, Worsley KJ. How many subjects constitute a study? Neuroimage. 1999 Jul;10(1):1-5. — View Citation
Ghez C, Hening W, Gordon J. Organization of voluntary movement. Curr Opin Neurobiol. 1991 Dec;1(4):664-71. Review. — View Citation
Hallet M, cloninger CR, Fahn S, Halligan P, Jankovic J, Lang AE, Voon V Psychogenic movement disorders and other conversion disorders. Cambridge University Press 2011
Rothwell JC, Traub MM, Day BL, Obeso JA, Thomas PK, Marsden CD. Manual motor performance in a deafferented man. Brain. 1982 Sep;105 (Pt 3):515-42. — View Citation
Sabes PN. The planning and control of reaching movements. Curr Opin Neurobiol. 2000 Dec;10(6):740-6. Review. — View Citation
Stone J, Carson A, Sharpe M. Functional symptoms in neurology: management. J Neurol Neurosurg Psychiatry. 2005 Mar;76 Suppl 1:i13-21. Review. — View Citation
van Beers RJ, Baraduc P, Wolpert DM. Role of uncertainty in sensorimotor control. Philos Trans R Soc Lond B Biol Sci. 2002 Aug 29;357(1424):1137-45. Review. — View Citation
Vuilleumier P, Chicherio C, Assal F, Schwartz S, Slosman D, Landis T. Functional neuroanatomical correlates of hysterical sensorimotor loss. Brain. 2001 Jun;124(Pt 6):1077-90. Erratum in: Brain. 2016 May;139(Pt 5):e29. — View Citation
Wolpert DM, Ghahramani Z, Jordan MI. An internal model for sensorimotor integration. Science. 1995 Sep 29;269(5232):1880-2. — View Citation
* Note: There are 17 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Familiarization with the joystick. | HHSC-JOY-I from Current Designs. They are asked to trace a straight line. | 30 minutes | |
Primary | Brain MRI | One hour and a half |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT00276887 -
Cognitive Behavior Therapy for Somatization Disorder
|
Phase 2 | |
Enrolling by invitation |
NCT05565352 -
Observation of Ketamine Treatment Safety and Tolerability in Adult Psychiatry Clinic Medical University of Gdańsk Inpatients
|
||
Active, not recruiting |
NCT04847310 -
Cost-benefit Evaluation of a Transdiagnostic Psychological Treatment for Emotional Disorders in Primary Care
|
N/A | |
Completed |
NCT05631860 -
Psychological Risk Factors for Functional Somatic Disorders
|
||
Completed |
NCT05611606 -
Welfare Benefits in Functional Somatic Disorders
|
||
Completed |
NCT02151500 -
Stress and Health Interview for Primary Care Patients With Medically Unexplained Symptoms
|
N/A | |
Completed |
NCT01590992 -
Treatment of Globus Sensations With Psychotherapy
|
N/A | |
Completed |
NCT00368212 -
Integrated Treatment Program for Hypochondriasis in Primary Care Settings
|
Phase 3 | |
Completed |
NCT00149799 -
Effectiveness of Escitalopram in the Treatment of Body Dysmorphic Disorder
|
Phase 3 | |
Terminated |
NCT03904784 -
School Withdrawal in Adolescents
|
||
Recruiting |
NCT04807933 -
Neurovegetative Decoupling in Somatoform Disorders : Biofeedback Interest
|
N/A | |
Completed |
NCT01119469 -
Comparing Cognitive Therapy and Exposure Therapy in Individuals With Hypochondriasis
|
Phase 3 | |
Recruiting |
NCT03188861 -
Systematic Screening for Comorbid Psychological Conditions in Cardiac ACSC Patients With Multimorbidity in the ED
|
||
Recruiting |
NCT04835103 -
Build a Research Clinic for Somatoform Patients
|
N/A | |
Completed |
NCT02346071 -
Acceptance and Commitment Group Therapy for Adolescents With a Range of Functional Somatic Syndromes
|
N/A | |
Completed |
NCT01518647 -
Acceptance and Commitment Therapy for Patients With Multi-organ Bodily Distress Syndrome (Stress-4)
|
N/A | |
Completed |
NCT01518634 -
Imipramine Treatment for Patients With Multi-organ Bodily Distress Syndrome
|
Phase 2 | |
Recruiting |
NCT01391897 -
Epigenetics of Posttraumatic Stress Disorder and Somatoform Disorders in the Course of Psychotherapy
|
N/A | |
Completed |
NCT01924715 -
Evaluating the Cost Effectiveness of ISTDP: A Quasi Experimental Study
|
N/A | |
Completed |
NCT00130988 -
DEPENAS: A Psychosocial Intervention for Patients With Medically Unexplained Symptoms
|
Phase 3 |