Solid Tumours Clinical Trial
Official title:
Compassionate Use Individual Request Program for GSK525762 in NUT Midline Carcinoma
Compassionate use access to molibresib/GSK525762 for eligible participant with NUT Midline Carcinoma; indication is a seriously debilitating or life-threatening disease.
Investigational Product GSK525762 is an orally bioavailable small molecule that is a potent
inhibitor of the binding of BET proteins to acetylated histones. Binding of GSK525762 induces
squamous differentiation and inhibits proliferation of patient-derived NMC cell lines both in
culture and in murine xenografts.
Compassionate use access to molibresib is restricted to patients with confirmed diagnosis of
NUT Midline Carcinoma.
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