Solid Tumours Clinical Trial
Official title:
Utility and Work Productivity Data for Economic Evaluation of Breast Cancer Therapies in the Netherlands and Sweden
Introduction: Many reimbursement authorities use economic evaluation to help guide decisions
regarding the adoption of new treatments in reimbursement systems. Survival and quality of
life are often the main measure of benefit used in an economic evaluation - expressed as a
quality adjusted life year (QALY). In addition though, some decision makers will also
consider the impact of a treatment on a patient's ability to continue working (expressed in
terms of productivity). The aim of the present study is to estimate quality of life weights
(utilities) and productivity loss for women with metastatic breast cancer (Human Epidermal
Growth Factor Receptor 2 positive or HER 2+).
Methods: Separate surveys will be used to assess utilities and productivity in HER2+
metastatic breast cancer (MBC). To capture utilities health state descriptions or vignettes
describing progressive disease, stable disease, and seven grade 3/4 adverse events
(diarrhoea, fatigue, anaemia, leukopenia, anorexia, decreases in left ventricular ejection
fraction (LVEF), and skin rash) will be developed. The vignettes will be developed based on
a literature review and in depth interviews with women with MBC in the Netherlands and
Sweden. Clinical experts in both countries will review the health states for content
validity. The health states will be translated using forward and back translation. Members
of the general public will rate the states (100 men and women in NL; 100 women aged 50+ in
Sweden) using the visual analogue scale and Time Trade Off method to determine utility
values. In a separate survey women who are currently being treated or have recently
completed their treatment for MBC will be surveyed regarding the impact of disease on their
ability to work using a validated work productivity measure (Work Productivity and Activity
Impairment) in women in the Netherlands and Sweden.
n/a
Time Perspective: Cross-Sectional
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