Solid Tumors Clinical Trial
Official title:
A Multi-Center, Open-Label, Single-Arm, Phase 1, Dose Escalation Study of ASONEP (Sonepcizumab/LT1009) Administered as a Single Agent Weekly to Subjects With Refractory Advanced Solid Tumors
The purpose of this study is to determine the safety, tolerability and highest dose of ASONEP that can safely be administered to patients with cancer who are no longer being helped by standard treatments.
ASONEP™ (sonepcizumab/LT1009) is a humanized monoclonal antibody that possesses
anti-angiogenic and anti-tumor activity in animal models of human cancer. ASONEP™ binds
sphingosine 1-phosphate (S1P), a bioactive lipid signaling molecule that possesses potent
pro-growth effects.
Preclinical studies with ASONEP™ (sonepcizumab/LT1009) and LT1002 (murine homolog of LT1009),
demonstrate the potential of an anti-S1P treatment to reduce tumor volumes and metastatic
potential, likely as a result of inhibiting new blood vessel formation needed to support
tumor growth.
Lpath is developing ASONEP™ (sonepcizumab/LT1009) for the following therapeutic indication:
ASONEP™ [parenteral sonepcizumab (LT1009) for the treatment of cancer] is indicated for use
in combination with TBD cytotoxic agents and other anti-angiogenic agents as second-line
therapy to treat patients with an unresectable, locally advanced, recurrent or metastatic TBD
cancer.
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Status | Clinical Trial | Phase | |
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Active, not recruiting |
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