Solid Tumors Clinical Trial
Official title:
Peritumoral Injection of Immature Dendritic Cels to Irradiated Metastases of Solid Tumors
Melanoma is the main cause of death in patients with skin cancer. Once it has metastasized,
this cancer has been shown to respond to chemotherapy only in rare cases. Immunotherapy
represents an approach to treatment based on the immune response to cancer antigens.
The long-term objective of this study is to develop a therapeutic approach for the treatment
of cancer in general, and melanoma in particular, based on immunotherapy, using a
combination of local tumor irradiation followed by injection of immature dendritic cells
(iDC).The treatment will be followed by the injection of interferon alpha, which we expect
will induce activation of the iDC.
This trial is based on the hypothesis that local radiation, which causes destruction of the
tumor, in combination with injection of the patient's own iDC and the activation of these
cells with interferon alpha, will induce an effective immune response against the tumor. In
order to test the suggested approach, we propose a 20-patients clinical trial that will
evaluate the objective clinical and immunological response to the proposed treatment in
patients with malignant melanoma and other solid tumors.
n/a
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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