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NCT00033215 Clinical Trial

A Phase 1 Study of S-3304 in Patients With Solid Tumors

Solid Tumors Clinical Trial

Official title:
A Phase 1 Study of S-3304 in Patients With Solid Tumors

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00033215
Other study ID # 0110P1416
Secondary ID
Status Completed
Phase Phase 1
First received April 9, 2002
Last updated April 24, 2018
Start date November 2001
Est. completion date March 12, 2003

Study information
Verified date April 2018
Source Shionogi Inc.
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

To determine the maximum tolerated dose and safety profile of S-3304 in patients with biopsy accessible cancer who have failed previous therapy or to whom no standard therapies are available. To determine the pharmacokinetic profile of S-3304 in this patient population

Recruitment information / eligibility
Status Completed
Enrollment 32
Est. completion date March 12, 2003
Est. primary completion date February 13, 2003
Accepts healthy volunteers No
Gender All
Age group 18 Years to 85 Years
Eligibility Inclusion criteria:

- Biopsy proven diagnosis of solid tumor(s) with biopsy accessible lesion(s)

- Must be able to tolerate oral medication Exclusion criteria

- Patients with other serious illnesses

- Patients who are receiving treatments

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• S-3304

Locations
Country Name City State
United States Roswell Park Cancer Center Buffalo New York
United States Cleveland Clinic Foundation Cleveland Ohio
United States University of Colorado Hospital Denver Colorado
United States H. Lee Moffitt Concer Center and Research Institute Tampa Florida

Sponsors (1)
Lead Sponsor Collaborator
Shionogi

Country where clinical trial is conducted

United States, 

References & Publications (1)

Chiappori AA, Eckhardt SG, Bukowski R, Sullivan DM, Ikeda M, Yano Y, Yamada-Sawada T, Kambayashi Y, Tanaka K, Javle MM, Mekhail T, O'bryant CL, Creaven PJ. A phase I pharmacokinetic and pharmacodynamic study of s-3304, a novel matrix metalloproteinase inh — View Citation

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