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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT06339541
Other study ID # 029-FPO23
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date June 5, 2023
Est. completion date December 1, 2024

Study information

Verified date March 2024
Source Fondazione del Piemonte per l'Oncologia
Contact Enzo Medico, MD
Phone +390119933234
Email enzo.medico@ircc.it
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The ACC Preclinical Research Platform for Precision Oncology is a retrospective and prospective observational study focused on the implementation and validation of the application of PDCM (Patient Derived Cancer Models) generated from tissues or cells of patients with neoplastic disease, as a tool to improve molecular and biological knowledge of tumours and to test the efficacy and sensitivity of pharmacological treatments.


Description:

This is a retrospective and prospective observational study, focused on the implementation and validation of the application of PDCM, generated from tissue or cells of patients, including paediatric patients, with solid and haematological malignancies, as a tool to improve molecular and biological knowledge of tumours and to test the efficacy and sensitivity of pharmacological treatments. An up-to-date database of all PDCMs available at the participating italian hospitals will be generated and enriched with new models generated during the course of the project. The sharing of models and procedures between the different hospitals will facilitate their molecular and phenotypic characterisation, also in parallel with the tumours of origin, as well as their validation as tools for testing the efficacy of drugs for precision medicine. By establishing common workflows and standards and performing cross-validation experiments it is planned to build a network of reference centres as a resource for drug screening on 2D and 3D models.


Recruitment information / eligibility

Status Recruiting
Enrollment 250
Est. completion date December 1, 2024
Est. primary completion date June 1, 2024
Accepts healthy volunteers No
Gender All
Age group 14 Years and older
Eligibility Inclusion Criteria: - Patients, including paediatric patients, with solid and haematological malignancies for whom tissue or tumour cell material is available. Exclusion Criteria: - none

Study Design


Related Conditions & MeSH terms


Locations

Country Name City State
Italy Fondazione del Piemonte per l'Oncologia-IRCCS Candiolo Candiolo Turin

Sponsors (2)

Lead Sponsor Collaborator
Fondazione del Piemonte per l'Oncologia Alleanza Contro il Cancro

Country where clinical trial is conducted

Italy, 

Outcome

Type Measure Description Time frame Safety issue
Primary number of PDCM (patient derived cancer models) PDCM will be generated from tissues and cells 12 months
Primary number of Whole Exome Sequencing (WES) e RNA-seq performed WES and RNA seq will be performed on tissues and blood 12 months
Secondary number of PDCM shared within the network PDCM will be generated from tissues and cells and shared within the network 12 months
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