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A Study of SPX-303, a Bispecific Antibody Targeting LILRB2 and PD-L1 in Patients With Solid Tumors — SPX-303  

Solid Tumor Clinical Trial

Official title:
A Phase 1, Open-label Study to Evaluate Safety, Tolerability, and Pharmacokinetics of an Anti-LILRB2 / PD-L1 Bispecific Antibody SPX- 303 in Patients With Solid Tumors

Clinical Trial Summary

Part 1 of this study is an open-label, dose-escalation, and safety expansion study of an anti-LILRB2 / anti-PD-L1 bispecific antibody SPX- 303 in patients with solid tumors. Part 2 of this study is an indication-specific dose expansion study of SPX-303.

Clinical Trial Description

This study is an open-label, dose escalation study of SPX-303 monotherapy to evaluate safety and tolerability, and to identify the MTD or MAD as well as evaluate preliminary anti-tumor efficacy, pharmacokinetics, and pharmacodynamics of various doses of SPX- 303 in patients with measurable disease who have progressed on or after prior therapy and who are not eligible or decline treatment options. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06259552
Study type Interventional
Source SparX Biotech(Jiangsu) Co., Ltd.
Contact SparX Biotech
Phone 847-739-6251
Email SPX-303@sparxbio.com
Status Recruiting
Phase Phase 1
Start date March 20, 2024
Completion date September 2027
View Details
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