HCW9218 in Select Advanced Solid Tumors

Status Active, not recruiting

Clinical Trial Summary

This is a single center, Phase I dose finding study of HCW9218 for the treatment of advanced/metastatic solid tumor cancer (except pancreatic and primary brain cancers). HCW9218 is a novel bi-functional fusion protein complex administered by subcutaneous (SC) injection. It is comprised of a soluble fusion of two human TGFβRII domains, human tissue factor, and human IL-15, and a second soluble fusion of two human TGFβRII domains and a sushi domain of human IL-15Rα. HCW9218 activates IL-15R signaling on effector immune cells and the dimeric TGFβRII functions as a "trap" for all three human TGF-β isoforms.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05322408
Study type	Interventional
Source	Masonic Cancer Center, University of Minnesota
Contact
Status	Active, not recruiting
Phase	Phase 1
Start date	April 1, 2022
Completion date	February 2026

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See also
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