Solid Tumor Clinical Trial
Official title:
A Prospective Study of the Relevance of the HLA-G Immune Checkpoint in Cancer Immunotherapy
Therapeutic targeting of immune checkpoints PD-1/PD-L1 and/or CTLA-4 is efficient in several
solid cancer subtypes, however only some patients do experience clinical benefit from these
treatments. One explanation could be that multiple redundant checkpoints are present within
the tumor, simultaneously keeping in check the patient's immune response. The immune
checkpoint HLA-G is neo-expressed in over 50% of cases in some cancer subtypes and associated
with more dismal prognosis. The immunosuppressive effects of HLA-G may result in resistance
to current immunotherapy drugs.
The GEIA study explores the impact of HLA-G tumor expression on the efficacy of cancer
immunotherapy in solid cancer patients.
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