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Clinical Trial Summary

The purpose of this trial is to define an effective and safe dose of AP-002 in advanced or recurrent solid tumors for which there are no standard therapies to use in subsequent studies in advanced or recurrent breast, non-small cell lung cancer (NSCLC) or prostate cancers.


Clinical Trial Description

The Phase 1 portion of this study will determine the Pharmacodynamically Active Dose (PAD) of AP-002 in humans, defined as the dose at which the plasma concentration of AP-002, as measured by Ga, is 300-500 ng/mL and which is at or below the Maximum Tolerated Dose (MTD), to use in the clinical setting of advanced or recurrent solid tumors. This will be followed by a Phase 2 expanded cohort treated at the PAD, to estimate the efficacy of AP-002 in patients with advanced or recurrent breast cancer, NSCLC and prostate cancer.

Patients will receive AP-002 orally, once daily for 14 days of a 21 day cycle. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04143789
Study type Interventional
Source Altum Pharmaceuticals INC
Contact Dawn East, BSN,RN
Phone 9544330329
Email deast@altumpharma.com
Status Recruiting
Phase Phase 1/Phase 2
Start date September 27, 2019
Completion date April 2021

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