Solid Tumor Clinical Trial
Official title:
Phase I, Traditional 3+3, Trial of PO Sorafenib and Topotecan in Refractory or Recurrent Pediatric Solid Malignancies
H. Lee Moffitt Cancer Center and Research Institute will be the Sunshine Project
Coordinator, but will not be recruiting locally.
The purpose of this research study is to establish a dose of the combination of drugs,
Topotecan and Sorafenib in children. This will be called the maximum tolerated dose. The
chemotherapy in this study is a combination of Topotecan and Sorafenib. The investigators
are trying to find the highest dose of Topotecan and Sorafenib that can be given safely to
children with Refractory or Recurrent Pediatric Solid Malignancies. The investigators will
do this by testing different doses of these drugs in different groups of children. The
investigators will also study how the body processes these drugs.
n/a
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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