Soft Tissue Sarcoma Clinical Trial
Official title:
Observational - SNP Array Analysis of Undifferentiated Sarcomas
This clinical trial studies biomarker differences in samples from patients with undifferentiated sarcomas. Studying biomarker in tissue samples from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer
Study Subtype: Ancillary/Correlative Observational Study Model: Cohort Time Perspective:
Prospective Biospecimen Retention: Samples With DNA Biospecimen Description: Tissue Study
Population Description: Patients from ARST0332 study Sampling Method: Non-Probability Sample
PRIMARY OBJECTIVES:
I. To determine what proportion of unclassifiable sarcomas are unclassifiable because the
initial evaluation was not sufficiently comprehensive versus what proportion can be regarded
as "true" undifferentiated sarcoma when a comprehensive assessment has been performed.
II. To develop formal diagnostic criteria for establishing the diagnosis of undifferentiated
sarcoma.
III. To determine whether undifferentiated sarcoma can be subdivided into separate and
distinct pathologic entities that are distinguishable by light microscopy,
immunohistochemistry, single nucleotide polymorphism (SNP) array profiling, or clinical
features.
IV. To determine whether undifferentiated sarcomas with specific "actionable mutations" can
be identified based on their histologic appearance, immunohistochemical staining
characteristics, or SNP array profiling features.
OUTLINE:
Tissue samples are analyzed for loss of heterozygosity (LOH) and SNP array profiling using
microarray and immunohistochemistry.
;
Observational Model: Case-Crossover, Time Perspective: Retrospective
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