Soft Tissue Sarcoma of Members Clinical Trial
Official title:
Randomised Multicentric Phase III Study Comparing Observation Versus Post-surgery Radiotherapy After Complete Exeresis With Margins Greater Than or Equal to 1 cm in Soft Tissues Members Sarcoma.
Soft tissue sarcomas represent less than 1% of malignant tumors in adults and sarcomas
members represent 60% of them.
These rare tumors involve complex multidisciplinary care better in centers having expertise.
Loco-regional therapy strategies have evaluated over time for tumors of members leading to
propose more often the combination of a large conservative tumor excision with radiotherapy.
Results have been demonstrated equivalent to those of an amputation in terms of local control
and survival.
The local recurrence rate for sarcomas of the members of any kind after surgery with or
without radiotherapy in the literature varies from 10 to 30%.
The main objective is to achieve a low recurrence rate while maintaining the function. The
question remains the possibility of an absence of irradiation in selected cases in a
de-escalation therapy order.
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