Oxytocin Effects on Self and Other Processing

Social Behavior Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02963194
• Other study ID #: UESTC-neuSCAN-05
• Status: Completed
• Phase: N/A
• First received: April 15, 2016
• Last updated: November 9, 2016
• Start date: November 2015
• Est. completion date: June 2016

Study information

• Verified date: November 2016
• Source: University of Electronic Science and Technology of China
• Contact: n/a
• Is FDA regulated: No
• Health authority: China: Sichuan Department of Science and Technology
• Study type: Interventional

Clinical Trial Summary

To determine whether the neuropeptide oxytocin (OXT) influences self-processing by investigating whether it increases the endowment effect in relation to both self and others.

Description:

In a double-blind, between- subject placebo (PLC) controlled design, investigator aimed to measure the effect of intranasal OXT on the endowment effect. All subjects completed a range of questionnaires measuring personality and affective traits and levels of anxiety before self-administration: Positive and Negative Affect Schedule (PANAS) , State-Trait Anxiety Inventory (STAI) , Beck Depression Inventory (BDI), self-esteem scale (SES). Subjects were asked to decide whether to buy or sell their own or others' (their mothers'/ fathers'/ classmate'/ strangers') possessions at various prices. Indifference point and brain activation were inluded into analysis as dependent variables.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 44
• Est. completion date: June 2016
• Est. primary completion date: March 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 27 Years

Eligibility

Inclusion Criteria:

• healthy subjects without past or current psychiatric or neurological disorders

Exclusion Criteria:

• history of head injury;

• claustrophobia;

• medical or psychiatric illness.

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Social Behavior

Intervention

Drug:
• Oxytocin

• Placebo

Locations

Country	Name	City	State
China	School of Life Science and Technology, University of Electronic Science and Technology	Chengdu	Sichuan

Sponsors (1)

Lead Sponsor	Collaborator
University of Electronic Science and Technology of China

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Compared the indifference point between buy and sell conditions during the price phase and the specific brain region activation between oxytocin and placebo groups	Indifference point is the gap between willingness to accept and willingness to pay ;focus on the specfic brain region relasted to self-processing, such as medial prefrontal cortex, precuneus, posterior cingulate cortex, ventral striatum.	1 hour	No