Screening to Improve Survival in AL Amyloidosis

Status Completed

Clinical Trial Summary

The purpose of this study is to see whether certain genes may be linked with the development of AL amyloidosis in subjects 60 years of age or older with the blood disorders SMM and MGUS. A limited repertoire of immunoglobulin (Ig) variable region genes have been associated with AL amyloidosis. The clonal plasma cells of subjects with SMM and MGUS may express one of these Ig variable region genes indicating a risk of progression to AL amyloidosis and potentially enabling early diagnosis. We hope this study will help us begin to understand whether Ig variable region gene identification can be a useful tool for assessing a subject's risk of progression to AL amyloidosis.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Amyloidosis
Immunoglobulin Light-chain Amyloidosis
Monoclonal Gammopathy of Undetermined Significance
Multiple Myeloma
Paraproteinemias
Smoldering Multiple Myeloma

Clinical Trial Details

NCT number	NCT04615572
Study type	Observational
Source	Tufts Medical Center
Contact
Status	Completed
Phase
Start date	August 28, 2020
Completion date	July 6, 2023

View Details

See also
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