Acute Cardiovascular Effects of Cigarette Smoking

Smoking Clinical Trial

Official title:

Acute Cardiovascular Effects of Cigarette Smoking

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01346956
• Other study ID #: 02AMCRAVSAND07
• Status: Completed
• Phase: N/A
• First received: May 2, 2011
• Last updated: May 3, 2011
• Start date: July 2002
• Est. completion date: August 2002

Study information

• Verified date: January 2003
• Source: Andhra Medical College
• Contact: n/a
• Is FDA regulated: No
• Health authority: India: Drugs Controller General of India
• Study type: Observational

Clinical Trial Summary

Twenty healthy smokers will be subjected to measurement of Pulse, Blood Pressure, electrocardiogram (ECG) and Echo at baseline and after smoking a cigarette. The measurements will be compare for any cardiovascular effects of a cigarette smoking on these parameters.

Description:

Twenty male persons habituated to smoking (at least 5 cigarettes/day) will be recruited after an informed consent. Healthy persons with no systemic illness will be included. After a history and a routine examination, subjects will be asked to abstain from smoking for 3 hours and then their pulse, BP, ECG and echo recorded. The measurements will be repeated after 15 min. and the average of these two taken as baseline readings. Then, they will be asked to smoke a cigarette and the measurements taken again. Special focus will be on Doppler measures of left ventricular (LV) function. The measurements are repeated immediately and at 5,10 and 15 min. The data will be analyzed for any cardiovascular effects of smoking a cigarette. Chi square test for proportions and t-test for means will be done. A p value < 0.05 will be taken as significant.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: August 2002
• Est. primary completion date: August 2002
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Healthy male smokers (at least 5 cigarettes /day) >18 years old.

Exclusion Criteria:

• Any cardiac or respiratory or systemic illness,including hypertension.

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

• Smoking

Locations

Country	Name	City	State
India	Andhra Medical College	Visakhapatnam	Andhra Pradesh

Sponsors (1)

Lead Sponsor	Collaborator
Andhra Medical College

Country where clinical trial is conducted

India,