Smoking and Peptidoglycan Recognition Protein-1 and Initial Periodontal Therapy

Smoking, Cigarette Clinical Trial

Official title:

The Effect of Smoking on Gingival Crevicular Fluid Peptidoglycan Recognition Protein-1 Level Following Initial Periodontal Therapy in Chronic Periodontitis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03915730
• Other study ID #: 2016/026
• Status: Completed
• Phase: N/A
• Start date: August 2016
• Est. completion date: November 2017

Study information

• Verified date: April 2019
• Source: Kirikkale University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

A total of 40 patients with CP (20 smokers (S+CP) and 20 nonsmokers (S-CP)) and 40 periodontally healthy subjects (20 smokers (S+PH) and 20 nonsmokers (S-PH)), comprising 80 subjects, were included in this study. Baseline GCF samples were obtained from all subjects and clinical periodontal measurements, including probing depth (PD), clinical attachment level (CAL), plaque index (PI), and gingival index (GI), were recorded. In patients who had received initial periodontal therapy, GCF samples were obtained and all clinical periodontal measurements were recorded again during the 6th-8th weeks. GCF PGRP-1 levels were analyzed by enzyme-linked immunosorbent assay.

Description:

Peptidoglycan recognition proteins (PGRPs) are one of the antimicrobial peptides that play a role in innate immunity and act against the bacterial cell wall. Smoking is the most important environmental risk factor for periodontitis. This study determined the effect of smoking on PGRP-1 levels in gingival crevicular fluid (GCF) in smokers and nonsmokers with chronic periodontitis (CP) following initial periodontal therapy.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 80
• Est. completion date: November 2017
• Est. primary completion date: July 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 22 Years to 56 Years

Eligibility

Inclusion Criteria:

• Clinical diagnosis of severe chronic periodontitis

• Clinical diagnosis of periodontal health

Exclusion Criteria:

• have any systemic disease,

• to be alcohol consumer,

• to receive any periodontal therapy in the past 6 months,

• to take any drugs regularly

• to be pregnant and/or lactate.

Related Conditions & MeSH terms

• Chronic Periodontitis
• Smoking, Cigarette

Intervention

Other:
• Initial periodontal therapy
Scaling and root planing and polishing with specific curettes were performed to patients with CP and oral hygiene education was provided to each patient.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Kirikkale University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in peptidoglycan recognition protein-1	Total amount of Peptidoglycan Recognition Protein-1 (µg) in gingival crevicular fluid	Baseline and 3 months
Secondary	Change in periodontal clinical parameter	Clinical attachment level (mm) (from cemento-enamel junction to the base of periodontal pocket)	Baseline and 3 months