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Combining Varenicline and Guanfacine for Smoking Cessation

Smoking Cessation Clinical Trial

Official title:
Combining Varenicline and Guanfacine for Smoking Cessation

Clinical Trial Summary

The novel design of this study combines a laboratory paradigm to evaluate stress-induced smoking behavior and smoking-related reinforcement, followed by a 12-week treatment phase to evaluate clinical outcomes.

Clinical Trial Description

Using a double-blind, this Phase 2 study will randomize 140 smokers to a parallel group design (varenicline + guanfacine vs. varenicline alone). Following titration to steady state levels, the investigators will evaluate sex differences in medication effects on stress-induced smoking behavior and smoking-related reinforcement in the laboratory, and on abstinence outcomes during a subsequent 12-week treatment period. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04198116
Study type Interventional
Source Yale University
Contact Sabrina Coppola
Phone 203-737-2827
Email sabrina.coppola@yale.edu
Status Recruiting
Phase Phase 2
Start date November 1, 2020
Completion date August 31, 2024
View Details
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