Smoking Cessation Clinical Trial
Official title:
Evaluation of the Efficacy of Low-frequency rTMS on Craving in Smoking Dependence: Single-centre Randomized, Controlled Blinded Pilot Study
The fight against smoking is a public health priority. Without help, fewer than 5% of des
smokers are abstinent at 12 months after smoking cessation.
Despite well-managed attempts at smoking cessation with nicotine substitutes, the rate of
success at 12 months in patients dependent on nicotine is only 18%. Moreover, other
therapeutic strategies (acupuncture, hypnosis…) have not proved to be effective.
The investigators propose a new therapeutic strategy for smoking cessation, which is based
on associating nicotine substitutes (to reduce physical symptoms of weaning from nicotine)
with rTMS at 1 Hz to the right DorsoLateral PreFrontal Cortex (DLPFC) for 2 weeks (to
diminish craving for tobacco). The principal objective is to improve the success rate for
smoking cessation attempts in patients who are highly dependent on nicotine, and who have
failed using usual smoking cessation strategies.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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