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Genetically Informed Smoking Cessation Trial — GISC  

Smoking Cessation Clinical Trial

Official title:
Genetically Informed Smoking Cessation Trial

Clinical Trial Summary

The investigators' goal is to identify the most appropriate smoking cessation treatments for smokers based on genetic information. Smokers try to quit smoking but relapses are common.

Clinical Trial Description

The investigators' goal is to determine whether genetic markers can be used to optimize smoking cessation pharmacotherapy to enhance efficacy, medication adherence, and reduce side effects. Smoking is a leading cause of preventable death and disability, and smoking cessation reverses the risk of mortality. However, cessation failure is common despite available cessation medications, which are associated with different efficacy, side effects, adherence, use constraints, and costs. This challenge can be addressed by improving current treatments via personalized medicine based on individual genetic markers to maximize efficacy and minimize side effects.

The investigators propose a prospective, genotype-based stratified randomization trial to compare two smoking cessation medications (combination NRT [patch and lozenge], varenicline vs. placebo) for 3 months in 720 smokers with known genotypes. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02351167
Study type Interventional
Source Washington University School of Medicine
Contact
Status Completed
Phase Phase 4
Start date May 20, 2015
Completion date August 31, 2019
View Details
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