Small Cell Lung Carcinoma Clinical Trial
Official title:
Collaborative Advanced Stage Tissue Lung Cancer (CASTLE) Network
The purpose of this study is to facilitate application of the known biomarkers to patients presenting today, and to establish a collection of biospecimens that will be useful for discovering and validating new biomarkers for future use.
Because of the historically poor outcomes of lung cancer patients, suboptimal therapeutic
efficacy, and significant side effects of chemotherapy, and the need to choose more
efficacious treatment regimens, and patients most likely to benefit from them, there is a
need to predict a priori whether an individual patient's tumor will respond to a particular
therapeutic agent. However, virtually all lung cancer tumor samples available today are from
resection specimens so direct, intra-patient molecular-clinical therapy correlations are
impossible.
Without the critical mass of tissue and data necessary to identify optimal molecular targets
for lung cancer and drugs active against these targets, new discoveries that offer the only
hope of long-term survival for many lung cancer patients remain elusive.
This study facilitates the collection of biospecimens from advanced lung cancer patients and
routine determination of a panel of documented clinically significant biomarkers. In
addition, it will centrally integrate and standardize research tissue samples with
corresponding proteomic, genomic, molecular and clinical data across a multitude of
institutions and oncology networks
;
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