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Study of Sintlimab Maintenance Therapy in Patients With Extensive Small Cell Lung Cancer

Small Cell Lung Cancer Clinical Trial

Official title:
Clinical Study of Sequential Sequential Sintilimab Maintenance Therapy in Patients With Extensive Small Cell Lung Cancer After Chemotherapy Combined With Adoptive Cellular Immunotherapy

Clinical Trial Summary

Small cell lung cancer is a highly aggressive malignancy. Currently, there is no effective regimen for patients after the progression offirst-line chemotherapy. The prognosis of patients with extensive disease is very poor, and the improved therapeutic efficacy is urgently needed. Most patients with small cell lung cancer have a long history of smoking, and the tumor mutation burden is relatively high, which provides potential for immunological checkpoint inhibitors represented by PD-1 antibodies. A number of studies have shown that chemotherapy combined with adoptive cellular immunotherapy could prolong the survival of patients. This study is a clinical study to explore the efficacy and safety of maintenance therapy with sintilimab after 4-6 cycles of first-line chemotherapy combined with adoptive cellular immunotherapy in patients with advanced small cell lung cancer.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03983759
Study type Interventional
Source Henan Cancer Hospital
Contact Quanli Gao, Dr.
Phone +86-15038171966
Email gaoquanli2015@126.com
Status Recruiting
Phase Phase 2
Start date June 20, 2019
Completion date May 31, 2021
View Details
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