Small Cell Lung Cancer Clinical Trial
Official title:
Mesylate Apatinib Combined With Irinotecan in Treatment of Recurrent Small Cell Lung Cancer: A Randomized Controlled Clinical Trial
The aim of the study is to evaluate the safety and efficacy of apatinib mesylate tablets and chemotherapy drug Irinotecan in treatment of recurrent SCLC stage IIIB&IV patients. It is a randomized controlled clinical trial.
Apatinib mesylate is a new inhibitor of VEGFR-2 tyrosine kinase targeting the intracellular
ATPbinding site of the receptor.
This research needs participants satisfied following criteria:
1. Aged between 18 and 70；
2. Locally advanced/metastatic small lung cancer (IIIB/IV) confirmed by pathology with
measurable lesions；
3. Patients who was treated by platinum chemotherapy drugs（including sensitive recurrency
and resistant recurrency）
4. ECOG：0-2；
5. the function of primary organs is normal.
6. Patients voluntarily entered the study and signed informed consent form (ICF).
The primary goal of this research choose ORR, DCR and adverse effects as main curative effect
criteria. PFS, OS and QoL as secondary curative effect criteria.
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