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Atezolizumab After Concurrent Chemo-radiotherapy Versus Chemo-radiotherapy Alone in Limited Disease Small-cell Lung Cancer — ACHILES  

Small-cell Lung Cancer Clinical Trial

Official title:
A Randomized Phase II Study Comparing Atezolizumab After Concurrent Chemo-radiotherapy With Chemo-radiotherapy Alone in Limited Disease Small-cell Lung Cancer

Clinical Trial Summary

Some patients with limited disease small-cell lung cancer (LD SCLC) are cured after chemo-radiotherapy, but the majority relapse and die from their cancer. Better therapy is needed. Immunotherapy represents the largest advance in cancer therapy in recent years and has demonstrated promising activity in SCLC. In this study we will investigate whether atezolizumab prolongs survival in LD SCLC patients who have undergone chemo-radiotherapy.

Clinical Trial Description

Patients who have - completed 4 course of platinum/etoposide and thoracic radiotherapy of 45 Gy/30 fractions, 2 fractions per day - non-progression after chemo-radiotherapy - ECOG performance status 0-2 will be randomized to receive atezolizumab 1200 mg IV every 3 weeks in 12 months or standard of care (observation). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03540420
Study type Interventional
Source Norwegian University of Science and Technology
Contact
Status Active, not recruiting
Phase Phase 2
Start date July 31, 2018
Completion date April 2027
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