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Inhibition of CArbonic Anhydrase in Combination With Platinum and Etoposide-based Radiochemotherapy in Patients With Localized Small Cell Lung Cancer — ICAR  

Small Cell Lung Cancer Clinical Trial

Official title:
Phase I Trial of Carbonic Anhydrase Inhibition Associated With Platinum-based Chemotherapy and Etoposide in Concomitance With Radiotherapy in Localized Small Cell Lung Carcinomas

Clinical Trial Summary

The investigators propose to study the carbonic anhydrase inhibition (acetazolamide) associated with concomitant radiochemotherapy in localized small cell lung cancer due to: 1. The over-expression of carbonic anhydrases in this type of cancer, 2. The Anti-tumor effect in preclinical acetazolamide in various tumor lines including neuroendocrine tumor lines, 3. The observed synergy between irradiation and inhibition of carbonic anhydrases, 4. Potential anti-tumor immune effect caused by decreased extracellular acidity.

Clinical Trial Description

Compared with healthy cells, glucose metabolism is greatly modified in cancer cells because of their highly proliferative character. This differential tumor / healthy tissue property is an opportunity to be able to propose a treatment whose therapeutic gain can be major (targeted treatment). Preclinical studies are multiple and showed that the targeting of overexpressed proteins (carbonic anhydrases) and involved in glycolytic metabolism can lead to a significant anti-tumor effect. This has never been tested in humans. Acetazolamide is a molecule commonly used for non carcinologic purposes but has demonstrated anti-tumor activity in preclinical studies; there is also synergy radiotherapy / targeting of carbonic anhydrases. Therefore, the investigators propose to study the combination of acetazolamide / radiotherapy / chemotherapy with platinum and etoposide in localized Small Cell Lung cancer. This would be the first study: - targeting glucose metabolism, - testing the effectiveness of acetazolamide in oncology, - testing the synergy radiotherapy / targeting glycolytic metabolism, - trying to manipulate the anti-tumor immune system indirectly, by decreasing extracellular acidosis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03467360
Study type Interventional
Source Centre Antoine Lacassagne
Contact Jérôme Doyen, MD
Phone +33492031270
Email jerome.doyen@nice.unicancer.fr
Status Recruiting
Phase Phase 1
Start date August 2, 2019
Completion date April 27, 2027
View Details
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