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NCT05910762 Clinical Trial

Human Learning of New Structured Information Across Time and Sleep

Sleep Clinical Trial

Official title:
Learning Novel Structure Across Time and Sleep

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05910762
Other study ID # 833228B
Secondary ID R01MH129436
Status Recruiting
Phase N/A
First received
Last updated
Start date June 5, 2023
Est. completion date March 2028

Study information
Verified date July 2023
Source University of Pennsylvania
Contact Anna C Schapiro, PhD
Phone 6177974555
Email aschapir@sas.upenn.edu
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Acting adaptively requires quickly picking up on structure in the environment and storing the acquired knowledge for effective future use. Dominant theories of the hippocampus have focused on its ability to encode individual snapshots of experience, but the investigators and others have found evidence that it is also crucial for finding structure across experiences. The mechanisms of this essential form of learning have not been established. The investigators have developed a neural network model of the hippocampus instantiating the theory that one of its subfields can quickly encode structure using distributed representations, a powerful form of representation in which populations of neurons become responsive to multiple related features of the environment. The first aim of this project is to test predictions of this model using high resolution functional magnetic resonance imaging (fMRI) in paradigms requiring integration of information across experiences. The results will clarify fundamental mechanisms of how humans learn novel structure, adjudicating between existing models of this process, and informing further model development. There are also competing theories as to the eventual fate of new hippocampal representations. One view posits that during sleep, the hippocampus replays recent information to build longer-term distributed representations in neocortex. Another view claims that memories are directly and independently formed and consolidated within the hippocampus and neocortex. The second aim of this project is to test between these theories. The investigators will assess changes in hippocampal and cortical representations over time by re-scanning participants and tracking changes in memory at a one-week delay. Any observed changes in the brain and behavior across time, however, may be due to generic effects of time or to active processing during sleep. The third aim is thus to assess the specific causal contributions of sleep to the consolidation of structured information. The investigators will use real-time sleep electroencephalography to play sound cues to bias memory reactivation. The investigators expect that this work will clarify the anatomical substrates and, critically, the nature of the representations that support encoding and consolidation of novel structure in the environment.

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Study Design

Related Conditions & MeSH terms

Intervention

Behavioral:
• Associative inference
Participants will engage in an associative inference paradigm. Memory will be assessed behaviorally and neural representations will be assessed using functional magnetic resonance imaging.
• Category learning
Participants will engage in a category learning paradigm. Memory will be assessed behaviorally (Arms 2 and 3), and neural representations will be assessed using functional magnetic resonance imaging (Arm 2).
• Sleep
Participants will sleep after engaging in a category learning paradigm while electroencephalography data are collected, and memory will be assessed behaviorally after sleep.

Locations
Country Name City State
United States University of Pennsylvania Philadelphia Pennsylvania

Sponsors (2)
Lead Sponsor Collaborator
University of Pennsylvania National Institute of Mental Health (NIMH)

Country where clinical trial is conducted

United States, 

References & Publications (56)

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Outcome
Type Measure Description Time frame Safety issue
Primary Changes in multivariate representations Changes in spatial correlations between the MRI BOLD pattern associated with related objects over the course of learning and across the one-week delay. Within first session (spanning 2-3 hrs.) and at approximately one week delay in second session (spanning 1-2 hrs.)
Primary Brain-behavior correlations Correlations between BOLD signal in the brain and participant behavior during judgments about objects. Within first session (spanning 2-3 hrs.) and at approximately one week delay in second session (spanning 1-2 hrs.)
Primary Correlations between activity across brain regions Relationships between BOLD activity across different regions of the brain as a function of trial type and delay. Within first session (spanning 2-3 hrs.) and at approximately one week delay in second session (spanning 1-2 hrs.)
Primary Memory accuracy Change in generalization ability from before to after the nap as a function of the different conditions of object cueing during sleep. Within single study session (spanning 4-5 hrs.)
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