Sleep Clinical Trial
Official title:
Modulation of Memory Consolidation in Humans
Verified date | June 2024 |
Source | University Medicine Greifswald |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The goal of the present study is to optimize effects of slow oscillatory transcranial direct current stimulation (so-tDCS) on sleep physiology and memory consolidation in humans by combining computational and experimental human models in an iterative process. The investigator therefore works in cooperation with Prof. Dr. Klaus Obermayer (TU Berlin), who contributes computation models with the aim to mechanistically understand the impact of different perturbations on sleep-related electrophysiological features, and to subsequently optimize so-tDCS parameters for inducing SO and spindle activity.
Status | Completed |
Enrollment | 54 |
Est. completion date | January 31, 2021 |
Est. primary completion date | January 5, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 50 Years to 80 Years |
Eligibility | Inclusion Criteria: - Adults aged between 50-80 years - screened as healthy in a structured telephone interview Exclusion Criteria: - Mini Mental Status Examination scores below 24 - history of severe untreated medical, neurological, and psychiatric diseases - sleep disorders - alcohol or substance abuse - brain pathologies identified on MRI scan - intake of medication acting primarily on the central nervous system (e.g., antipsychotics, antidepressants, benzodiazepines, or any type of over-the-counter sleep-inducing drugs such as valerian), - nonfluent German language abilities. |
Country | Name | City | State |
---|---|---|---|
Germany | University medicine Greifswald | Greifswald |
Lead Sponsor | Collaborator |
---|---|
University Medicine Greifswald | Technische Universität Berlin |
Germany,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Changes in EEG power (µV²) of the slow oscillation frequency band (0.5-1 Hz) following so-tDCS during sleep | Investigation whether 7 different protocols of anodal tDCS (including SHAM) lead to distinct changes in slow oscillation power | up to 20 weeks | |
Primary | Changes in EEG power (µV²) of the sleep spindles frequency band (12-15 Hz) following so-tDCS during sleep | Investigation whether 7 different protocols of anodal tDCS (including SHAM) lead to distinct changes in sleep spindle power | up to 20 weeks | |
Primary | Changes in cross-frequency coupling (resultant vector length) between slow oscillations and sleep spindles following so-tDCS during sleep | Investigation whether 7 different protocols of anodal tDCS (including SHAM) lead to distinct changes in coupling between slow oscillations and sleep spindles | up to 20 weeks | |
Secondary | Sleep architecture | Proportion of time spent in different sleep stages (in %) during the entire nap and following so-tDCS | up to 20 weeks | |
Secondary | Changes in EEG power (µV²) of the delta frequency band (1-4 Hz) following so-tDCS during sleep | Investigation whether 7 different protocols of anodal tDCS (including SHAM) lead to distinct changes in delta power | up to 20 weeks |
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