Melatonin and Vaccine Response, Immunity, and Chronobiology Study — MAVRICS  

Sleep Clinical Trial

Official title: Melatonin and Vaccine Response, Immunity, and Chronobiology Study (MAVRICS): The Impact of Sleep, Circadian Health, and Melatonin on Vaccine Immunogenicity and Outcomes

Status Active, not recruiting

Clinical Trial Summary

This study will evaluate the impact of sleep, circadian health and melatonin on flu vaccine immunogenicity.

Clinical Trial Description

Vaccination is critical to public health and disease prevention. However, despite the many scientific advancements and vaccines on the market, they are not always fully effective. Adjuvants are often used to boost immunity, but they are associated with more side effects, possible allergic reactions and public mistrust that supports vaccine hesitancy. Many factors affect vaccine efficacy and host immunity. Sleep, circadian health and melatonin have been studied in the past to affect immune response to vaccines and infection. Patient education about better sleep habits and/or melatonin use are potentially safe, cost effective, and accessible interventions that may improve host immunity and vaccine effectiveness. However, neither have been studied rigorously and at this time, are not actively implemented in the clinical arena. Hence, we propose a study comparing vaccine immunogenicity based on sleep quality, chronotype, and exogenous melatonin. ;

Related Conditions & MeSH terms

• Chronobiology Disorders
• Circadian Rhythm Disorders
• Sleep
• Vaccine Response

• NCT number: NCT04953754
• Study type: Interventional
• Source: Walter Reed National Military Medical Center
• Status: Active, not recruiting
• Phase: N/A
• Start date: October 25, 2022
• Completion date: June 2025