Perioperative Lignocaine and Sleep Disturbance

Sleep Disturbance Clinical Trial

Official title: Effect of Peroperative Intravenous Infusion of Lignocaine on the Quality of Postoperative Sleep

Status Not yet recruiting

Clinical Trial Summary

The aim of this clinical trial is to study the effect of an intravenous infusion of lidocaïne in a multimodal analgesic protocol on the architecture sleep during the first postoperative night.

Clinical Trial Description

To study the effect of lidocaïne, we plan to include 40 patients, randomized in 2 groups, undergoing open prostate surgery in this randomized placebo-controlled trial.

Before anesthesia induction, these patients receive an intravenous lidocaine infusion (bolus 1,5 mg.kg-1 followed by a continuous infusion of 2mg.kg-1.h during 24 hours) or an equal volume of placebo. Then the anesthesia is induced with propofol, sufentanil et rocuronium. The postoperative analgesia is provided by paracetamol, tramadol and patient-controlled analgesia (PCA) with morphine or oral oxycodone. A polysomnography is registred on the preoperative night and on the first postoperative night. ;

Related Conditions & MeSH terms

• Dyssomnias
• Parasomnias
• Sleep Disturbance
• Sleep Wake Disorders

• NCT number: NCT03317912
• Study type: Interventional
• Source: University Hospital of Liege
• Contact: Isabelle Maquoi
• Phone: 32 4 366 7179
• Email: i.maquoi@gmail.com
• Status: Not yet recruiting
• Phase: Phase 4
• Start date: December 2017
• Completion date: December 2018