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NCT06452459 Clinical Trial

Glymphatic MRI Study

Sleep Deprivation Clinical Trial

Official title:
Evaluation of Glymphatic Function With MRI

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT06452459
Other study ID # IT Gadolinium Study
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date July 1, 2024
Est. completion date July 1, 2028

Study information
Verified date June 2024
Source Oregon Health and Science University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This study aims at identifying neuroimaging markers of glymphatic function in humans.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 10
Est. completion date July 1, 2028
Est. primary completion date July 1, 2027
Accepts healthy volunteers
Gender All
Age group 18 Years to 89 Years
Eligibility Inclusion Criteria: - Ability to undergo MRI without anesthesia - Calculated GFR greater or equal to 60 mL/min/1.73 m2 Exclusion Criteria: - Inability to obtain consent - Subject is incarcerated, pregnant, or lactating or suspects they may be pregnant - Known allergic or hypersensitivity reactions to gadolinium - Three or more drug allergies from separate drug classes - Recent or expected beed for imaging with iodinated contrast - Contraindications to MRI: claustrophobia, weight greater than maximum MRI scanner capacity, presence of metallic foreign body, or implanted devices not documented as MRI safe - History of neurosurgical procedure or cervical surgery - Current use of anticoagulation medications - Contraindication to lumbar puncture (creatinine or INR elevated above laboratory standard cutoffs)

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• No interventinon
No intervention is anticipated. This is an observational study.

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Oregon Health and Science University

Outcome
Type Measure Description Time frame Safety issue
Primary Contrast enhancement Measurement of contrast intensity in brain parenchyma 2 weeks
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