Sleep Deprivation Clinical Trial
Official title:
Investigation of the Effects of Sleep Provocations on Itch and Pain Sensitivity
In This experiment, the investigators would like to test following hypotheses regarding the influence of sleep deprivation on itch: - To investigate similarity and differences between itch and pain by comparing the effect of sleep deprivation in them. - To evaluate the inflammatory state induced by sleep fragmentation via the analysis of C-reactive protein (CRP) levels from blood samples. - To correlate the anxiety and depression scores (evaluated through questionnaires) with itch and pain sensitivity and evaluate how they are affected by sleep. In This experiment, the investigators would like to test following hypotheses regarding the influence of sleep fragmentation on itch: - To investigate similarity and differences between itch and pain by comparing the effect of sleep deprivation in them. - To evaluate the inflammatory state induced by sleep fragmentation via the analysis of C-reactive protein (CRP) levels from blood samples. - To correlate the anxiety and depression scores (evaluated through questionnaires) with itch and pain sensitivity and evaluate how they are affected by sleep deprivation.
Chronic itch affects approximately a fifth of the global population and is associated with substantial negative consequences for the affected individuals. Furthermore, there is a lack of efficient treatment options for chronic itch. Poor sleep is a common companion of itch and is often reported by patients with chronic itch. Poor sleep is often characterized by nightly awakenings and troubles falling asleep. This is a significant problem as poor sleep in general is associated with lowered quality of life. While previous research has already established the negative impact of itch on sleep, it is yet to be studied whether the opposite tendency might be true as well. Knowledge about patients with chronic pain has shown that poor sleep can increase the sensitivity to pain and inflammation, and this tendency can also be observed in healthy participants after experimental sleep provocations. Therefore, the investigators wish to investigate how sleep provocations affect markers of itch in healthy participants. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05956886 -
Sleep Chatbot Intervention for Emerging Black/African American Adults
|
N/A | |
Completed |
NCT02996864 -
Location-based Smartphone Technology to Guide College Students Healthy Choices Ph II
|
N/A | |
Completed |
NCT03129204 -
Sensation Awareness Focused Training for Spouses
|
N/A | |
Withdrawn |
NCT04049682 -
Start Times and Restful Sleep
|
||
Completed |
NCT03182413 -
Impact of THN102 on Attention, Wakefulness and Cognitive Performance During Total Sleep Deprivation
|
Phase 1 | |
Not yet recruiting |
NCT01930279 -
Effect of Partial Sleep Deprivation on Immunological System in Peripheral Blood
|
N/A | |
Completed |
NCT01989741 -
Effect of Sleep Restriction on Decision Making and Inflammation
|
N/A | |
Completed |
NCT00228215 -
Tips for Infant and Parent Sleep (TIPS)
|
N/A | |
Completed |
NCT00123214 -
A Change in Diet May Decrease the Negative Consequences of Chronic Sleep Deprivation
|
N/A | |
Completed |
NCT00079664 -
Comparing Tai Chi Training to a Low-Stress Physical Activity to Enhance Sleep in Older Adults
|
Phase 1 | |
Completed |
NCT04179838 -
Olfactory Contributions to Sleep-dependent Food Craving
|
N/A | |
Not yet recruiting |
NCT05513339 -
Effect of Sleep Deprivation on Cognitive Function Among Cardiology Fellows
|
||
Recruiting |
NCT05026541 -
Resilience to Sleep Deprivation and Changes in Sleep Architecture in Shoonya Meditators
|
N/A | |
Withdrawn |
NCT04096261 -
The Importance of Sleep Quality and the Blood-brain Barrier in Cognitive Disorders and Alzheimer's Disease
|
||
Recruiting |
NCT06017882 -
Combined Effects of Acute Sleep Restriction and Moderate Acceleration (+Gz) on Physiological and Behavioral Responses to High Mental Workload
|
||
Completed |
NCT00179322 -
Effects of Sleep Deprivation and Recovery on Cognitive Functions
|
||
Recruiting |
NCT06399939 -
The Function of Biphasic Sleep in Infants
|
N/A | |
Not yet recruiting |
NCT06027047 -
Breakthrough Anxiety and Sleep Evaluation Using Linked Devices and Smartphone Application Onar (BASEL)
|
||
Completed |
NCT05162105 -
Quick Returns - Sleep, Cognitive Functions and Individual Differences
|
N/A | |
Completed |
NCT03981770 -
Characterisation of Gut Microbiota, Bispectral Index Data and Plasma Kynurenine in Patients Undergoing Thyroid Surgery
|