Sleep Deprivation Clinical Trial
Official title:
Protective Effects of Exercise Training on Endothelial Dysfunction Induced by Total Sleep Deprivation in Healthy Subjects
Rationale. Sleep loss is a risk factor for cardiovascular events mediated through
endothelial dysfunction.
Objective. To determine if 7 weeks of exercise training can limit cardiovascular dysfunction
induced by total sleep deprivation (TSD) in healthy young men.
Methods: 16 subjects will be examined during 40-h TSD, both before and after 7 weeks of
interval exercise training. Vasodilatation induced by ACh, insulin and heat (42°C) as well
as pulse wave velocity (PWV), blood pressure and heart rate (HR) will be assessed at
baseline, during TSD, and after one night of sleep recovery. Biomarkers of endothelial
activation, inflammation, and hormones will bemeasured from morning blood samples at 07:00
n/a
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention
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