Combined and Isolated Effects of Sleep Deprivation and Alcohol Intake on Exercise Performance in Humans.

Sleep Deprivation Clinical Trial

Official title:

Combined and Isolated Effects of Sleep Deprivation and Alcohol Intake on Cardiorrespiratory, Neuromuscular and Hormonal Responses in Healthy Males.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02117193
• Other study ID #: UFRGS 366465
• Status: Completed
• Phase: N/A
• First received: April 14, 2014
• Last updated: May 26, 2015
• Start date: October 2013
• Est. completion date: May 2015

Study information

• Verified date: May 2015
• Source: Federal University of Rio Grande do Sul
• Contact: n/a
• Is FDA regulated: No
• Health authority: Brazil: National Committee of Ethics in Research
• Study type: Interventional

Clinical Trial Summary

Although the effects of acute alcohol intake and sleep deprivation on exercise performance lacks evidence in the literature, in many situations, they occur simultaneously. Once the alcohol affects physiological processes, the processes that occur during sleep can be impaired, such as: suppression of GH release, action of neurotransmitters and neuromodulators in the CNS, changes in the proportion of sleep stages and may lead to suppression of REM sleep. These changes promote a significant functional impairment such as a reduction in alertness and modification in reaction time, which affects the performance of any activity of daily and professional life. However, the combined effects on the physical performance variables, such as aerobic and neuromuscular performance lack of evidence in the literature.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: May 2015
• Est. primary completion date: May 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• Physical active men

Exclusion Criteria:

• AUDIT questionnaire above 15 points

• Nocturnal Chronotype

• Skeletal muscle injuries in upper and lower limb

• Metabolic and cardiovascular disease

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Outcomes Assessor)

Related Conditions & MeSH terms

• Alcohol Drinking
• Alcohol Intake
• Sleep Deprivation

Intervention

Other:
• Alcohol intake
The subjects will be drink beer (with or without alcohol) before sleep intervention (normal sleep and sleep deprivation).
• Sleep deprivation
One night of sleep deprivation or one night of normal sleep.

Locations

Country	Name	City	State
Brazil	Exercise Research Laboratory	Porto Alegre	Rio Grande do Sul

Sponsors (3)

Lead Sponsor	Collaborator
Federal University of Rio Grande do Sul	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior., Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Brazil

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Aerobic performance		6 months	Yes
Primary	Neuromuscular performance		6 months	Yes
Primary	Biochemical responses	Cortisol, Adrenaline, Testosterone, CK, PCr, IL-6, IL-10, Glucose.	6 months	Yes
Secondary	Hydration status	Urine Specific Gravity	6 months	Yes
Secondary	Profile of Mood States		6 months	Yes
Secondary	Breath alcohol		6 months	Yes