Mechanisms of Prediabetic States in Sleep Apnea

Status Recruiting

Clinical Trial Summary

The purpose of this study is to better understand how sleep apnea contributes to the development of diabetes.

Clinical Trial Description

Substantial evidence indicates that obstructive sleep apnea (OSA) is associated with impaired glucose metabolism, however, metabolic mechanisms underlying this association remain unclear. This mechanistic study will determine systemic and cellular metabolic pathways that contribute to impaired glucose metabolism in obstructive sleep apnea (OSA). Understanding of how obstructive sleep apnea (OSA) affects glucose metabolism may help identify novel targets for risk prediction and/or treatment of metabolic impairments beyond continuous positive airway pressure (CPAP). Obstructive sleep apnea (OSA) patients with prediabetes will be studied under three in-laboratory conditions in a randomized cross-over design: untreated condition (obstructive sleep apnea), treated condition (continuous positive airway pressure), untreated but pharmacologically suppressed lipolysis condition (Niacin). The investigator will perform whole body and cellular assessments under each study condition. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04234217
Study type	Interventional
Source	University of Chicago
Contact	Becky Tucker, BA
Phone	773-702-2348
Email	sleepstudy@uchicago.edu
Status	Recruiting
Phase	N/A
Start date	November 26, 2019
Completion date	December 31, 2025

View Details

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