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Effects of Quetiapine on Sleep and Next Day Alertness in People With Obstructive Sleep Apnea — QOSA  

Sleep Apnea, Obstructive Clinical Trial

Official title:
Effects of Quetiapine on Sleep and Next Day Alertness in People With Obstructive Sleep Apnea

Clinical Trial Summary

Quetiapine is medication used to treat schizophrenia and bipolar disorder. Increasingly, low doses of quetiapine are prescribed "off-label" for insomnia. Quetiapine increases sleep duration with fewer interruptions, and people report feeling more rested. This accounts for why it is popular to prescribe for insomnia. Insomnia and obstructive sleep apnea (OSA) share many symptoms and differential diagnosis can be difficult. While quetiapine may improve sleep and breathing in certain people (i.e in light sleepers) an initial study indicated that quetiapine caused breathing disturbances in healthy individuals. Effects in OSA are unknown. In this placebo-controlled double blind study, participants with mild-moderate OSA will spend 2 nights in the sleep lab, one with quetiapine at a dose commonly prescribed for insomnia and one with placebo. The investigators will assess participants sleep by standard clinical sleep study, and morning alertness using questionnaires, reaction tests, and a driving simulator test.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05303935
Study type Interventional
Source Flinders University
Contact
Status Completed
Phase Phase 2
Start date May 25, 2022
Completion date April 4, 2023
View Details
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