Sleep Apnea, Obstructive Clinical Trial
Official title:
Microparticles as a Biomarker of Incident Cardiovascular Risk in Patients With Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is independently associated with cardiovascular diseases,
including myocardial infarction and stroke. OSA may promote atherosclerosis risk factors such
as hypertension, diabetes and dyslipidemia and may have direct proatherogenic effects on the
vascular wall. A growing number of studies have recently focused on the role of
microparticles (MPs) in the atherogenic process. Case-control studies have shown that
platelet-, endothelial- and leukocyte-derived MP levels are increased in OSA and that
leukocyte-derived MP are released during the night in OSA. Furthermore, experimental evidence
shows that MPs from OSA patients induce endothelial dysfunction.
The objective of this prospective study is to evaluate the impact of increased levels of
leukocyte derived MPs on the cardiovascular outcomes in patients with prevalent
cardiovascular diseases investigated for OSA.
MPs are small plasma membrane vesicles that can be released by a variety of vascular or blood
cells and that contain membrane and cytosolic elements. Case-control studies have shown that
platelet-, endothelial- and leukocyte-derived MP levels are increased in OSA. Experimental
evidence shows that MPs from OSA patients induce endothelial dysfunction, inflammation, and
vascular hyperreactivity when injected to mice.
The impact of increased levels of MPs on the cardiovascular prognosis in OSA patient with
prevalent cardiovascular diseases in unknown.
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