Effect of Modified Fujita Technique Uvulopalatoplasty on Oxidative DNA Damage Levels in Patients With Obstructive Sleep Apnea SyndromE (OSAS)

Sleep Apnea, Obstructive Clinical Trial

Official title:

Effect of Modified Fujita Technique Uvulopalatoplasty on Oxidative DNA Damage Levels in Patients With Obstructive Sleep Apnea SyndromE

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01635699
• Other study ID #: ATUNI-1
• Status: Completed
• Phase: N/A
• First received: July 4, 2012
• Last updated: July 6, 2012
• Start date: June 2008
• Est. completion date: March 2011

Study information

• Verified date: July 2012
• Source: Erzurum Regional Training & Research Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Turkey: Ministry of Health
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to determine the possible effects of uvulopalatopharngoplasty (UPPP) -which is a a therapy used on patients with Obstructive sleep apnea syndrome (OSAS- on oxidative damage.

Description:

Obstructive sleep apnea syndrome (OSAS) is a sydrome which has characteristic upper way obstruction and a decrease in blood oxygen saturation as sleeping. uvulopalatopharngoplasty (UPPP)is one of the surgical approaches applied to the patients with OSAS, since the oxidative damage markers have been found high in patients with OSAS. Although antioxidant levels were higher in patients with OSAS than those in normal population, there is report about the effect of UPPP on antioxidant status in patients with OSAS. We performed this study to confirm whether is there a We performed the present study to confirm whether there is a relationship between the OSAS and oxidative damage before and after UPPP.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 49
• Est. completion date: March 2011
• Est. primary completion date: June 2008
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients who underwent uvulopalatopharngoplasty (UPPP)for Obstructive sleep apnea syndrome (OSAS)

Exclusion Criteria:

• Anormal nasopharyngeal computed tomography, chronic diseases such as diabetes mellitus, hypertension etc.

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

• Apnea
• Sleep Apnea Syndromes
• Sleep Apnea, Obstructive

Locations

Country	Name	City	State
Turkey	Erzurum Regional Educational Researh Hospital	Erzurum

Sponsors (1)

Lead Sponsor	Collaborator
Erzurum Regional Training & Research Hospital

Country where clinical trial is conducted

Turkey,