| Eligibility |
Inclusion Criteria:
- Typical chordoma and chondroid chordoma of the skull base, spine or chordoma of sacral
region
- Patient undergoing an additional or exclusive radiotherapy (Photontherapy and/or
Prothontherapy)
- Age = 18 years old
- ECOG performance status 0 to 2
- Satisfying biological functions 28 days before inclusion :
1. Haemoglobin = 9 g/dL
2. Neutrophils = 1500/mm3
3. Platelets = 100 000/mm3
4. ASAT, ALAT, GGT, PAL = 1.5 N, bilirubin = 40 µmol/L, LDH = 1.5 N
5. Creatininemia < 1.5 N
- Satisfying vital cardiac and respiratory functions
- Neurologic functions well stabilised
- Effective contraception for women of childbearing age during the the protontherapy
treatment and during the month following the end of treatment. A pregnancy test shall
be negative at inclusion.
- Patient covered by health insurance
- Patient provided with information and signature of informed consent.
Exclusion Criteria:
- Dedifferentiated chordomas, chondrosarcoma
- History of cancer (except cutaneous basocellular epithelioma or epithelioma of the
uterine cervix) having recurred in the 5 years preceding entry in the trial and no
relapse in the last 3 years
- Metastatic patient
- History of brain radiation therapy, or base of the skull or spinal segments to be
treated
- Contraindications to radiotherapy
- Contraindications to PET/CT examinations [18F] Fluorodexoxyglucose (FDG) and [18]FAZA
- Associated pathology likely to prevent the patient from receiving treatment,
- Incompatible treatment with the inclusion in the study (oxygen therapy, EPO,
anti-vascular treatments, anti-angiogenic treatments)
- Patient already included in another therapeutic trial with an experimental medication,
- Patient currently nursing,
- Persons deprived of their liberty, or under guardianship,
- Impossibility of undergoing the trial's medical follow-up for geographical, social or
psychological reasons.
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