Skin Toxicity Clinical Trial
Official title:
Evaluation of Topical Corticosteroids Potency in Combination Preparations in Healthy Volunteers
Several combination topical drugs are available on the market. The potency of corticosteroids
depends on a particular molecular structure and the skin penetration properties. Besides
molecular structure, a penetration of a corticosteroid molecule correlates with physical
properties of the vehicle which depend on physical properties of the vehicle constituents.
Vasoconstriction assay is considered as the gold standard for testing potency of topical
corticosteroids.
Primary outcome: Change in Vasoconstriction index following application of topical corticosteroids that are incorporated with or without an antibiotic and/or antifungal drugs in healthy volunteers. ;
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