Clinical Trials Logo

Clinical Trial Summary

The objective of this clinical trial is to determine the activity of dealcoholized muscadine wine to alleviate oxidative stress, inflammation, skin photoaging, and alter gut microbiome in women 40-67 years of age. The investigators hypothesize that dealcoholized muscadine wine daily for 42 days will significantly alleviate oxidative stress, inflammation, skin photoaging, and alter the gut microbiome in women compared to drinking sugar water.


Clinical Trial Description

Aging of the skin is characterized by wrinkling, sagging, and laxity. About 80% of facial skin aging is classified as extrinsic, or photoaging because it results from exposure to UV light of the sun that causes oxidative stress The remaining 20% of facial aging is the intrinsic type which is partially caused by the accumulation of proteins that are modified by reactive carbonyls in a reaction known as protein glycation. Aging also shifts the composition of the gut microbiome in at least 35 genera towards an unhealthy state of dysbiosis. Previous studies showed that muscadine polyphenols inhibited protein glycation under a simulated physiological condition. Additional experiments using cell culture and mice showed that dealcoholized muscadine wine alleviated inflammation and protected against dysbiosis in the gut. The objective of this research is to confirm the health benefits of muscadine wine polyphenols in a clinical trial. The investigators hypothesize that dealcoholized muscadine wine consumption in women 40-65 years old will alleviate skin photoaging and skin conditions by decreasing oxidative stress and inflammation. It is also expected to improve the composition of the gut microbiome. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04614753
Study type Interventional
Source University of Florida
Contact
Status Active, not recruiting
Phase N/A
Start date October 10, 2020
Completion date July 2, 2024

See also
  Status Clinical Trial Phase
Completed NCT04544982 - Study to Evaluate the Efficacy of Blue Fenugreek Kale Extract (BFKE) on Skin N/A
Completed NCT03346447 - Effect of Baby Wipe Solutions on Fecal Enzyme-induced Irritation N/A
Completed NCT05861622 - Examining the Efficacy of a Novel Moisturizer Across Eight Weeks N/A
Recruiting NCT06148740 - An Investigation of the Effects of a Skin Serum Containing Propolis on Skin Health and Appearance N/A
Active, not recruiting NCT06148766 - An Investigation of the Effects of a Royal Jelly and Bee Venom-Derived Skin Cream on Skin Health and Signs of Aging N/A
Active, not recruiting NCT06148753 - An Investigation of the Effects of a Royal Jelly and Bee Venom-Derived Skin Serum on Skin Health and Signs of Aging N/A
Completed NCT04511052 - Probiotics for Enhanced Tissue Carotenoid Status in Premenopausal Women Phase 1/Phase 2
Recruiting NCT05925712 - Aerofit Post Market Investigation N/A
Completed NCT02525224 - Nutritional Supplement Efficacy on Cellular Protection and Skin Health in Generally Healthy Adults N/A
Completed NCT04144777 - Efficacy of Solarplast for Health and Oxidative Stress N/A
Recruiting NCT04861623 - Effects of 100% Orange Juice on Skin Health in Women N/A
Completed NCT03771807 - Efficacy of a Nutritional Supplement on Skin Health in Generally Healthy Adults N/A
Recruiting NCT04183920 - To Determine the Activity and Mechanisms of Cranberries to Attenuate Skin Photoaging and Improve Skin Health in Women N/A
Completed NCT06452810 - A Clinical Trial to Evaluate the Effects of a Skin Balm on the Appearance of the Eye Area N/A
Completed NCT00864188 - The Influence of Probiotics in a Drinkable Yogurt on Skin Health Phase 1
Completed NCT03348917 - The Effect of Skin Cleansers on the Skin Surface Microbiome Phase 4
Withdrawn NCT03641430 - The Effects of Over-the-Counter Products on the Skin N/A
Recruiting NCT05128240 - Nutritional Study of Fish Oil in Skin Quality in Healthy Women N/A
Completed NCT00574574 - Effects of Anthocyanin on Skin Health and Markers of Cardiovascular Disease Risk N/A