Skin Disease Clinical Trial
Official title:
A Study to Document the Effect of Petrolatum on Innate Immune Responses in the Skin
Verified date | April 2016 |
Source | Rockefeller University |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Institutional Review Board |
Study type | Interventional |
Petrolatum is a very well-known emollient that has been used since the 1800's. Not only has
it been used to help with dry skin, but it is also marketed as a substance that protects
minor cuts and burns. In the past it was thought to be inferior to topical antibiotics in
infection prevention for cutaneous wounds. However, in 1996 a large, multicenter trial
including over 900 patients showed that petrolatum is as safe and effective as the topical
antibiotic, bacitracin in preventing infections for patients undergoing dermatological
surgery. In this trial, not only did the petrolatum group have similarly low rates of
infection, this group also reported no cases of contact dermatitis. Aside from being more
expensive than petrolatum, bacitracin and other topical antimicrobials (i.e. neomycin) have
been known as common culprits of contact dermatitis. In a study done by the North American
Contact Dermatitis Group between 2005-2006, 9.2 and 10% of the over 4,000 patients who were
patch tested had an allergic reaction to either bacitracin or neomycin, respectively. For
the above reasons, it is clear that petrolatum is an appealing alternative to topical
antibiotics for infection prevention in patients undergoing dermatological procedures. This
study however lacked any mechanistic analyses to provide molecular insight as to how
petrolatum was effective at infection prevention.
The aim of this research is to study the effect of petrolatum on innate immune reactions in
the skin. In particular, petrolatum's effect on various antimicrobial peptides after contact
with the skin for 3 days will be examined. This will be done through immunohistochemistry
for various cellular infiltrates as well as mRNA gene expression via RT-PCR analysis for
inflammatory and AMP genes. Tissue samples of petrolatum occluded skin will be compared to
both healthy skin and skin under occlusion alone as controls. These comparisons will isolate
the effect of the petrolatum on the skin.
Status | Completed |
Enrollment | 20 |
Est. completion date | February 2015 |
Est. primary completion date | February 2015 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 85 Years |
Eligibility |
Inclusion Criteria: - Healthy male or female between 18 and 85 years of age - Able to give verbal and written informed consent Exclusion Criteria: - Subjects taking any of the following systemic or topical therapies (on the back) within 2 weeks of enrollment: corticosteroids, immunosuppressants, and/or any other medications that may affect the outcome of the study - subjects with history of keloids - subjects with self reported history of hepatitis B or C - HIV positive |
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
Country | Name | City | State |
---|---|---|---|
United States | The Rockefeller University | New York | New York |
Lead Sponsor | Collaborator |
---|---|
Rockefeller University |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The skin samples will be subjected to gene expression analysis of AMPs to determine those that are up regulated as compared to our controls (both healthy appearing skin and skin subject to occlusion alone). | 3 days | No | |
Secondary | Skin samples will be analyzed by immunohistochemistry for various cell infiltrates | 3 days | No |
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