Fermented Grape Combined With Fruits and Vegetables Drink on Anti-aging and Anti-inflammatory

Skin Condition Clinical Trial

Official title:

Fermented Grape Drinks Made of Fermented Grapes With Fruit and Vegetable Powder to Explore Whether it Can Improve the Skin's Condition and Achieve Anti-inflammatory Effects.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04805697
• Other study ID #: 20-054-B
• Status: Completed
• Phase: N/A
• Start date: October 1, 2019
• Est. completion date: October 31, 2020

Study information

• Verified date: March 2021
• Source: TCI Co., Ltd.
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

60 subjects were recruited and divided into placebo group and fermented grape drinks group.

Description:

In this study, using a fermented grape drinks made of fermented grapes with fruit and vegetable powder to explore whether it can improve the skin's condition and achieve anti-inflammatory effects. Sixty subjects were recruited and divided into placebo group and fermented grape drinks group. After drinking for 8 weeks, skin test and blood biochemical analysis were performed.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: October 31, 2020
• Est. primary completion date: August 31, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 65 Years

Eligibility

Inclusion Criteria:

1. Dry skin.

2. Rough skin

3. Large pores

4. Dark yellow complexion

5. Sagging skin

Exclusion Criteria:

1. Skin disorders

2. Liver diseases

3. Kidney diseases

4. Allergy to cosmetics, drugs, or foods

5. Pregnant and lactating women

6. People who had any cosmetic procedures before 4 weeks of the study

7. Area of facial spot over 3 cm2

8. Vegan

9. People who took collagen supplements in the past 3 months.

Related Conditions & MeSH terms

• Disease
• Skin Condition
• Skin Diseases

Intervention

Dietary Supplement:
• placebo group
subjects drank 50 ml , 1 bottle a day for 8 week
• fermented grape drinks
subjects drank 50 ml , 1 bottle a day for 8 week

Locations

Country	Name	City	State
Taiwan	Research & Design Center, TCI CO., Ltd	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
TCI Co., Ltd.

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	skin brightness	The subjects divided into a placebo group (n=30) and an experimental group (n=30). Each subject was informed to consume one bottle of a 50 mL of grape drink or a placebo drink daily for 8 weeks, then using corneometer CM825 to examine skin brightness (The higher the value, the more water content, C.U., corneometer units )	8 week
Primary	skin elasticity	The subjects divided into a placebo group (n=30) and an experimental group (n=30). Each subject was informed to consume one bottle of a 50 mL of grape drink or a placebo drink daily for 8 weeks, then using cutometer dual MPA580 to examine skin elasticity (The closer the R2 value is to 1, the better the elasticity and no unit)	8 week
Primary	skin moisture	The subjects divided into a placebo group (n=30) and an experimental group (n=30). Each subject was informed to consume one bottle of a 50 mL of grape drink or a placebo drink daily for 8 weeks, then using probe system GL2000 & MPA10 to examine skin moisture (The higher the value, the higher the gloss, no unit)	8 week
Primary	skin spot	The subjects divided into a placebo group (n=30) and an experimental group (n=30). Each subject was informed to consume one bottle of a 50 mL of grape drink or a placebo drink daily for 8 weeks, then usig VISIA-CR to examine skin spot (The higher the value, the larger the pore area, mm2)	8 week
Primary	skin wrinkle	The subjects divided into a placebo group (n=30) and an experimental group (n=30). Each subject was informed to consume one bottle of a 50 mL of grape drink or a placebo drink daily for 8 weeks, then using VISIOSCAN-VC20 to examine skin wrinkle (The higher the value, the more wrinkles, surface evaluation of wrinkles, SEW)	8 week
Primary	inflammatory cytokines	The subjects divided into a placebo group (n=30) and an experimental group (n=30). Each subject was informed to consume one bottle of a 50 mL of grape drink or a placebo drink daily for 8 weeks, then using ELISA kit to examine inflammatory cytokines (pg/ml)	8 week