Skin Cancer Clinical Trial
Official title:
Bioclinical Study of Scalp Photoaging of a Population Male Over 65 Years Old. Mono-centric Prospective Study
The aging of skin, especially that of the scalp, is a combination of intrinsic and extrinsic
aging factors secondary to the chronic sun exposure. For men with an alopecia genetic (= bald
men), the solar part, in skin aging process, is major.
The helio-dermal scalp is frequently the site of cancers mainly after 65 years. Objectives
are to identify specific biomarkers involved in the photo-aging of the alopecic scalp
Investigators can also hope to understand and to explain the inter-individual inequality of
the aging of skin. They can hope to a better understanding of the biological mechanisms
between photo-induced skin aging and photo-induced carcinogenesis.
Investigators propose to study 40 male patients aged 65 and over in order to compare the
state of aging of their scalp skin in the alopecic zone :
not hairy photo-exposed (= ZH sun damage zone) versus occipital hair zone protected photo (=
ZT control zone).
Patients will be recruited in the dermatology department of the St-Etienne University
Hospital who will benefit from the removal of a scalp tumour in the alopecic zone.
This study aims to identify biological markers, by transcriptomic analysis, associated with
aging of the scalp, by comparing for each patient the skin of the scalp exposed to the light
("ZH") to an unexposed witness skin ("ZT").
The study will include :
- examinations to characterize components of the scalp: transcriptomic, proteomic and
immunohistochemical analysis of skin biopsies, and a swab sampling will identify the
cutaneous microflora of the scalp
- noninvasive examinations, in vivo
;
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