Cabozantinib in Recurrent/Metastatic Merkel Cell Carcinoma

Status Terminated

Clinical Trial Summary

This is an open-label, non-randomized, phase 2 study to assess the feasibility of using cabozantinib in recurrent/metastatic Merkel Cell Carcinoma patients that progressed after platinum-based therapy.

Clinical Trial Description

Cabozantinib (XL184) is an inhibitor of multiple receptor tyrosine kinases and was approved by the U.S. Food and Drug Administration (FDA) on 29 November 2012 for the treatment of patients with progressive, metastatic medullary thyroid cancer. It is commercially available as COMETRIQ™ in the United States. During the Pre Treatment Period, participants are consented and qualified (screened) for the study. Treatment will be administered on an outpatient basis. Each treatment cycle lasts 28 days, during which time the participant will be taking the study drug, cabozantinib, once daily. The participant will be given a study drug-dosing diary for each treatment cycle. The diary will also include special instructions for taking the study drug. - Participants will be followed for 8 weeks after removal from study or until death, whichever occurs first. Participants removed from study for unacceptable adverse events will be followed until resolution or stabilization of the adverse event. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02036476
Study type	Interventional
Source	Dana-Farber Cancer Institute
Contact
Status	Terminated
Phase	Phase 2
Start date	February 2014
Completion date	July 2016

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT02721459` - XL888 + Vemurafenib + Cobimetinib for Unresectable BRAF Mutated Stage III/IV Melanoma	Phase 1
Completed	`NCT03740815` - Feasibility of Serratus Plane Block Associated With Sedation in Axillary Dissection	N/A
Recruiting	`NCT05779423` - Cryoablation+Ipilimumab+Nivolumab in Melanoma	Phase 2
Terminated	`NCT01468818` - Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Melanoma	Phase 2
Completed	`NCT01820234` - Evaluation of Store-and-Forward Teledermatology Versus a Face-to-Face Assessment During a Skin Cancer Screening Event	N/A
Completed	`NCT00535769` - Evaluation of Adherence to Topical Agents: Applying Communication Technology to Improve Sunscreen Use	Phase 0
Completed	`NCT00526032` - Melanoma Detection by Oblique-Incidence Optical Spectroscopy	N/A
Completed	`NCT00588341` - Phase II Trial of Neoadjuvant Temozolomide in Melanoma Patients With Palpable Stage III or IV Disease Undergoing Complete Surgical Resection	Phase 2
Active, not recruiting	`NCT01447199` - The Molecular Predisposition to Hereditary Nonpolyposis Colon Cancer (HNPCC)
Enrolling by invitation	`NCT04758988` - AI Augmented Training for Skin Specialists	N/A
Not yet recruiting	`NCT04534868` - Patient Acceptance And Satisfaction of Teledermoscopy In General Practice In a Belgian Rural Area	N/A
Recruiting	`NCT04138342` - Topical Fluorescent Nanoparticles Conjugated Somatostatin Analog for Suppression and Bioimaging Breast Cancer	Phase 1
Completed	`NCT03673917` - Cosmetology Students and Skin Cancer	N/A
Recruiting	`NCT04341064` - Sun-safe Habits Intervention and Education	Phase 3
Completed	`NCT04206995` - Cancer Sensing: Evaluation of Odour Sampling Techniques
Recruiting	`NCT05574101` - A Study of Radiation Therapy and Cemiplimab for People With Skin Cancer	Phase 2
Not yet recruiting	`NCT05860881` - Topical Sirolimus in Chemoprevention of Facial Squamous Cell Carcinomas in Solid Organ Transplant Recipients (SiroSkin)	Phase 3
Completed	`NCT05146622` - Virtual Sun Safe Workplaces Ph I
Recruiting	`NCT05068310` - Applicability of a Cellular Resolution Full-field OCT Image System for Pigmented and Non-pigmented Skin Tumors
Recruiting	`NCT03889899` - Alpha Radiation Emitters Device (DaRT) for the Treatment of Cutaneous, Mucosal or Superficial Soft Tissue Neoplasia.	N/A