Skin Aging Clinical Trial
— PEAU PROOFOfficial title:
Study of Skin Parameters in the PROOF Cohort
This study aims to evaluate skin aging of an homogeneous population of 77 years old patient
selected among the PROOF cohort who has been continuously investigated by cardiological
examination.
Skin aging will be explored by macroscopic and microscopic evaluation. In particular, skin
aging will be measured by an index of clinical aging (SCINEXA) and other complementary
measures such as facial photos, standard and High Definition dermoscopy, elastography,
sebumetry, in vivo and ex vivo confocal microscopy, and classical histological examinations.
Status | Completed |
Enrollment | 209 |
Est. completion date | December 2014 |
Est. primary completion date | March 2014 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 75 Years to 80 Years |
Eligibility |
Inclusion Criteria: - included in the PROOF cohort - Form consent signed Exclusion Criteria: - Past history of surgery and / or treatment of aesthetic medicine - neurological disorders - insulin-dependent diabetes, - corticosteroids or retinoids (isotretinoin, ...) > 1 year |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
France | CHU de Saint-Etienne | Saint-etienne |
Lead Sponsor | Collaborator |
---|---|
Centre Hospitalier Universitaire de Saint Etienne |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | SCINEXA score | The aging of the skin is evaluated by a semi-quantitative composite of 19 clinical variables : the score SCINEXA | Day 1 | No |
Secondary | in vivo confocal microscopy | Skin aging evaluated by in vivo confocal microscopy | Day 1 | No |
Secondary | ex vivo confocal microscopy | Skin aging evaluated by ex vivo confocal microscopy ( thickness of the epidermis with and without the stratum corneum, dermis thickness , number of sweat glands per unit volume). | Day 1 | No |
Secondary | histology | Skin aging evaluated by conventional histology (thickness of the epidermis and dermis, presence and degree of elastosis , flattening of the dermo- epidermal junction) | Day 1 | No |
Secondary | RAMAN | The composition of subcutaneous fat measured by ex vivo RAMAN spectroscopy | Day 1 | No |
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