Single Nucleotide Polymorphism Clinical Trial
Official title:
Pilot Study to Investigate Relationship Between Common Folate Gene Polymorphisms, Folate Status and Cellular Folate Speciation
This pilot study is designed to investigate differences in folate-related genes (single nucleotide polymorphisms) and their relationship to the species of folate present on red blood cells.
The main questions to be addressed in this pilot study are:
1. what is the type of folate in red blood cells in individuals with different
methylterahydrofolate reductase (MTHFR) genotypes
2. what is the relationship between other folate metabolism-related gene single nucleotide
polymorphisms and type (species) of folate found in red blood cells
3. what is the relationship between folate and other B vitamin status, genotype and folate
species
4. is there a relationship between serum ferritin status and folate metabolism
Whole blood will be taken from apparently healthy male and female volunteers, aged 18-65,
which will be used to determine genotype for various folate metabolism-related genes.
Furthermore, the type of folate present on the red blood cells will be assessed, and folate,
vitamin B12, riboflavin and serum ferritin status determined.
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