Silicosis Clinical Trial
Official title:
The Use of Forced Oscillation Technique in the Analysis of Respiratory System in Never-smoking Patients With Silicosis:Pathophysiological Study and Evaluation of Diagnostic Accuracy
Silicosis is a chronic and incurable occupational disease that can progress independent of
the end of exposure. Recent works suggest that the Forced Oscillation Technique (FOT) may
help to improve our understanding of the changes in lung mechanics, as well as in the
detection of these changes.
Objectives: Analyze the effects of airway obstruction in silicosis on the respiratory
impedance and evaluated the diagnostic use of the FOT in these patients. For this, the
investigators used spirometry to classify airway obstruction, which resulted in four
categories: control, patients with normal exam, mild obstruction, and moderate-to-severe
obstruction. Resistive data were interpreted using the zero-intercept resistance (R0), the
resistance at 4 Hz (Rrs4) and the mean resistance (Rm). The investigators also analyzed the
mean reactance (Xm) and the dynamic compliance (Crs,dyn). The total mechanical load was
evaluated using the absolute value of the respiratory impedance (Z4Hz). The diagnostic
potential was evaluated by investigating the area under the receiver operating
characteristic curve (AUC).
n/a
Time Perspective: Cross-Sectional
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