Nephropathy in Patients With Sickle Cell Disease

Sickle Cell Nephropathy Clinical Trial

Official title:

Pattern of Sickle Cell Nephropathy in Patients With Sickle Cell Disease

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03680547
• Other study ID #: npscd
• Status: Not yet recruiting
• Start date: May 1, 2020
• Est. completion date: January 1, 2021

Study information

• Verified date: November 2019
• Source: Assiut University
• Contact: fahim mohamed fahim
• Phone: 01002500073
• Email: fahim.osman[@]med.aun.edu.eg
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

There are some diseases that give rise to diverse renal manifestations as does sickle cell disease

Description:

Such involvement adversely affects virtually all major physiological processes in the kidney, and leads to complications that are common and chronic on the one hand (such as impaired urinary concentrating ability), and those that are rare and uniformly fatal on the other (such as renal medullary carcinoma) This steady adverse renal sequelae shortens the average lifespan of patients with SCD.

Proteinuria and a reduced glomerular filtration rate are risk factors associated with increased mortality among those patients with approximately 16-18% of overall mortality in this patient group is due to kidney disease.

Once end stage renal disease is reached, the mortality of patients who are on haemodialysis and have SCD is increased severalfold relative to the mortality of patients who are on haemodialysis but do not have SCD.

Thus,although the average lifespan of patients with SCD has increased during recent decades owing to improved management of complications outside the kidney,kidney disease contributes substantially to the still increased mortality in SCD.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 25
• Est. completion date: January 1, 2021
• Est. primary completion date: May 30, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 5 Months to 18 Years

Eligibility

Inclusion Criteria:

• All patients with sickle cell anemia attending the unit will be included in the study.

Exclusion Criteria:

• patient with any underlaying systemic diseases other than sickle cell anaemia

Related Conditions & MeSH terms

• Anemia, Sickle Cell
• Kidney Diseases
• Sickle Cell Nephropathy

Intervention

Other:
• patient with sickle cell disease
assess degree of renal affection in patientswith sickle cell disease attending Assuit university Children hospital by estimating some predictors of glomerular and tubular dysfunction.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	sickle cell nephropathy in patient with sickle cell disease	detection of renal impairment in patients with sickle cell disease by estamating gloerular and tubular dysfunction clinicaly and laboratory	one year