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Endothelial Function in Patients With Sickle Cell Anemia Before and After Sildenafil

Sickle Cell Anemia Clinical Trial

Clinical Trial Summary

The investigators would like to study the endothelial function in sickle cell patients without pulmonary hypertension in an in vivo method during a steady state condition before and after sildenafil treatment for 1 month, and to study the effects of this nitric oxide donor by measuring the Flow Mediated Dilatation, by measuring endothelial progenitor stem cells colonies, and by measuring the effect of therapy on markers of inflammation (cell adhesion molecules and cytokines).

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Bio-availability Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Caregiver, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00937144
Study type Interventional
Source The Baruch Padeh Medical Center, Poriya
Contact
Status Withdrawn
Phase Phase 4
Start date September 2009
Completion date February 2010
View Details
See also
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